Endocrine Abstracts

Levo-thyroxine (LT4) formulations are available on tablets (TAB) or liquid solution (SOL). LT4 TAB absorption could be affected by several gastric diseases as Helicobacter pylori (HP) infection or chronic atrophic gastritis (CAG), instead no data are available on absorption of the LT4 SOL in these conditions. The aim of the study was to compare the efficacy of TAB or SOL LT4 formulations in patients with dyspeptic syndrome (DS) and subclinical ...

Cushing disease and hypophosphatasia are rare conditions that may be both responsible of an important impairment of bone metabolism with increased fracture risk. We reported for the first time a case of a 43-year-old woman that came at our attention for recent onset of alopecia and amenorrhea. At the anamnesis, she denied any past relevant events and no drug assumption. At the physical examination, she presented rubeosis and facies lunaris and central adipose distribution (wai...

Monoclonal antibodies against the Programmed cell death-1 protein (PD-1) are a new treatment for advanced cancer. Endocrine and metabolic diseases are known to be frequently associated with this class of drugs. We describe two cases of Nivolumab-induced diabetes mellitus.Case 1: A 73-year-old man with a mutated BRAF-V600K advanced stage melanoma was treated with Nivolumab (240 mg IV every 2 weeks). He had normal-weight (BMI: 21.6 Kg/mq), and no previous ...

Multiple pituitary hormone deficit and hypothalamic obesity are common complications after brain surgery for childhood tumors. Despite adequate replacement hormone therapy, obesity develops equally, but liver failure is not usually described. In this study, four subjects who had undergone surgery for brain tumors involving the peri-hypothalamic area when they were nursing or as youths (9 months, 6 years, 9 years and 20 years). They were referred to our Unit when they were 19, ...

Congenital morphological alteration of anterior and/or posterior pituitary lobes is a rare disease often associated with isolated or multiple hormonal deficiency. In this study we re-evaluated 24 adult patients, 20 males and 4 females, (23–46 years), in whom Nuclear Magnetic Resonance (NMR) showed congenital morphological alteration of the gland. Twenty out of 24 patients presented with an association of hypoplasic adenohypophysis and ectopic neurohypophysis, while 4 pres...

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...

Pituitary adenomas constitute the third most common intracranial neoplasm. Adenoma cells either express no hormone (null cell adenoma) or hormones of different cell lineage. About 1% of pituitary adenomas shows a plurihormonal expression pattern, which may either be attributed to one cell lineage or rarely to different cell lineages. In addition, the development of separate pituitary adenomas may be observed in 0.5–1.5% of surgical specimens and in up to 10% of autopsy ca...

Background: Immune checkpoint inhibitors (ICI) have become a clinically validated treatment for numerous types of tumor including melanoma, lung, and kidney carcinoma. These treatments can cause immune-related adverse events affecting several organs including the endocrine system.Aims: The aim of this study was to characterize the type and the onset of the ICI associated-endocrinopathies.Materials and methods: This retrospective co...

Aim: To analyze the prevalence of anxiety and depression in a large cohort of adults affected by autoimmune diabetes and to identify the associated factors, stratifying them according to sex.Methods: We administered to 553 patients with autoimmune diabetes the questionnaires: Hospital Anxiety and Depression Scale (HADS), Diabetes Distress Scale, Diabetes-related Quality of Life and Diabetes Treatment Satisfaction Questionnaire. We excluded 119 patients w...

Aims: Narcolepsy with cataplexy (NC) is a rare, chronic disease, characterized by excessive daytime sleepiness, cataplexy, disrupted nocturnal sleep and manifestations of abnormal REM (Rapid Eye Movement) sleep. Human NC is probably caused by environmental and genetic factors, leading to dysfunctions in hypothalamic orexigenic neurons. Recent studies showed that NC was associated with an increase in Body Mass Index, despite a reduction in food intake. In the current study we i...